What sign indicates the patient with Parkinson's is due for their medication?

• A. Bradykinesia worsens
• B. Postural instability
• C. Tremor begins
• D. Rigid muscles

Answer: (C)

When managing Parkinson’s with dopaminergic therapy, symptoms tend to recur as the drug’s effect wears off. The clear, practical cue that a new dose is due is the return of the resting tremor. Tremor is typically well-controlled when the medication is active, so its reappearance signals that the medication window is ending and another dose is needed. While other off-period signs like increasing slowness (bradykinesia) or rigidity can also occur as the drug wears off, tremor reappearing is the most noticeable and reliable indicator that the next dose is due.