Which beverage should phenytoin not be taken with due to absorption interference?

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Multiple Choice

Which beverage should phenytoin not be taken with due to absorption interference?

Explanation:
Phenytoin absorption can be significantly reduced when taken with calcium-rich dairy products. The calcium in milk binds to phenytoin in the gut and forms insoluble complexes, which decreases the drug’s dissolution and uptake into the bloodstream. This lowers effective drug levels and can worsen seizure control. That’s why milk should be avoided at dosing times, and phenytoin is typically given with water instead. Coffee and juice don’t have the same calcium-chelation effect, so they don’t interfere with absorption in the same way, and water provides a neutral medium for taking the medication.

Phenytoin absorption can be significantly reduced when taken with calcium-rich dairy products. The calcium in milk binds to phenytoin in the gut and forms insoluble complexes, which decreases the drug’s dissolution and uptake into the bloodstream. This lowers effective drug levels and can worsen seizure control. That’s why milk should be avoided at dosing times, and phenytoin is typically given with water instead. Coffee and juice don’t have the same calcium-chelation effect, so they don’t interfere with absorption in the same way, and water provides a neutral medium for taking the medication.

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