Which drug class is used as abortive therapy for migraines?

• A. Beta-blockers
• B. ACE inhibitors
• C. Triptans
• D. Statins

Answer: (C)

Abortive therapy for a migraine attack relies on medications that rapidly interrupt the attack itself. Triptans fit this need because they are selective 5-HT1B/1D receptor agonists that act on the trigeminovascular system. By stimulating these receptors on cranial blood vessels and nerve terminals, they cause vasoconstriction and reduce the release of inflammatory neuropeptides, which together blunt the pain pathway and bring relief quickly, often within an hour or two. They’re best used at the first sign of a migraine and are intended for acute treatment, not prevention.

Other drug classes listed aren’t used to abort an attack. Beta-blockers are commonly used to prevent migraines, not to stop one once it starts. ACE inhibitors and statins address hypertension and lipid management, respectively, and do not provide the rapid abortive relief needed for an acute migraine.