Which statement about antihistamine use is incorrect?

• A. Antihistamines are generally safe to take with over-the-counter medications.
• B. Avoid activities that require alertness until you know how adverse effects are tolerated.
• C. Drink extra fluids if possible.
• D. Take the medication with food to minimize gastrointestinal distress.

Answer: (D)

Antihistamines commonly cause drowsiness, so you should avoid activities that require alertness until you know how the medication affects you. Hydration can help with dry mouth or throat irritation that some antihistamines cause, so drinking fluids is reasonable. However, taking the medicine with food to minimize gastrointestinal distress isn’t a general recommendation for antihistamines; many can be taken with or without food, and food can actually slow absorption for some formulations, delaying onset of relief. So that specific guidance isn’t a standard rule and isn’t necessary for most people using these drugs.